Presentation Type
Poster
Full Name of Faculty Mentor
Bryan Wakefield, Chemistry
Major
Biochemistry
Presentation Abstract
The flinderoles A-C are a class of anti-malaria bisindole alkaloids from plants of the Flindersia genus. Flinderole C was specifically from the Papua New Guinean plant called F. amboinensis and is the most potent antimalarial of the group. Malaria is a parasitic infectious disease usually found in the hot, tropic regions of the world, such as parts of Africa. It is estimated that nearly half the world's population lives in an area where it is endemic. Furthermore, malaria was estimated to have caused over 600,000 deaths in 2020. While measures to limit the spread of the disease lessen its impact, there is still a need for treatments. There are numerous drugs and naturally occurring products that have been used to treat malaria but many have lost their effectiveness due to drug resistance in the cells, so flinderoles could be a platform to build new drugs on. Through our research we are conducting a Friedel-Crafts reaction to produce a five membered ring of flinderole. We are attempting to generate an alcohol that is required for ring closure through a sequence using a lactone opening which will limit the steps necessary to make the allylic alcohol needed for the Friedel-Crafts reaction.
Start Date
12-4-2023 4:00 PM
End Date
12-4-2023 6:00 PM
Disciplines
Biochemistry
Recommended Citation
Pettijohn, Ana and Romain, Claire, "A New Approach to the Core of Flinderole C" (2023). Undergraduate Research Competition. 77.
https://digitalcommons.coastal.edu/ugrc/2023/fullconference/77
Included in
A New Approach to the Core of Flinderole C
The flinderoles A-C are a class of anti-malaria bisindole alkaloids from plants of the Flindersia genus. Flinderole C was specifically from the Papua New Guinean plant called F. amboinensis and is the most potent antimalarial of the group. Malaria is a parasitic infectious disease usually found in the hot, tropic regions of the world, such as parts of Africa. It is estimated that nearly half the world's population lives in an area where it is endemic. Furthermore, malaria was estimated to have caused over 600,000 deaths in 2020. While measures to limit the spread of the disease lessen its impact, there is still a need for treatments. There are numerous drugs and naturally occurring products that have been used to treat malaria but many have lost their effectiveness due to drug resistance in the cells, so flinderoles could be a platform to build new drugs on. Through our research we are conducting a Friedel-Crafts reaction to produce a five membered ring of flinderole. We are attempting to generate an alcohol that is required for ring closure through a sequence using a lactone opening which will limit the steps necessary to make the allylic alcohol needed for the Friedel-Crafts reaction.