Presentation Title
Alternative Methods in Synthesis of Phidianidine Analogues
Presentation Type
Event
Full Name of Faculty Mentor
Bryan Wakefield
Major
Chemistry
Presentation Abstract
Phidianidine is a natural alkaloid that is unique to other alkaloids by containing a natural oxadiazole structure. This molecule was discovered in a marine species Phidiana militaris and has many pharmaceutical potentials including being an agonist towards the µ-opioid receptor and inhibiting the growth of cancer cell lines. These characteristics makes phidianidine a desirable molecule for synthesis. The lynchpin of previous methods was the construction of the central 1,2,4-oxadiazole ring which limited the types of analogues that could be constructed. The objective of this research is to develop a synthetic method that enables the late-stage installation of a variety of moieties to create new analogues of this alkaloid for biological evaluation.
Course
CHEM*499*06
Location
Lib Jackson Student Union, Atrium
Start Date
16-4-2019 12:30 PM
End Date
16-4-2019 2:30 PM
Disciplines
Chemistry
Recommended Citation
Bialousow, Lucas, "Alternative Methods in Synthesis of Phidianidine Analogues" (2019). Undergraduate Research Competition. 31.
https://digitalcommons.coastal.edu/ugrc/2019/fullconference/31
Alternative Methods in Synthesis of Phidianidine Analogues
Lib Jackson Student Union, Atrium
Phidianidine is a natural alkaloid that is unique to other alkaloids by containing a natural oxadiazole structure. This molecule was discovered in a marine species Phidiana militaris and has many pharmaceutical potentials including being an agonist towards the µ-opioid receptor and inhibiting the growth of cancer cell lines. These characteristics makes phidianidine a desirable molecule for synthesis. The lynchpin of previous methods was the construction of the central 1,2,4-oxadiazole ring which limited the types of analogues that could be constructed. The objective of this research is to develop a synthetic method that enables the late-stage installation of a variety of moieties to create new analogues of this alkaloid for biological evaluation.
