CCU Digital Commons - Undergraduate Research Competition: Alternative Methods in Synthesis of Phidianidine Analogues
 

Presentation Title

Alternative Methods in Synthesis of Phidianidine Analogues

Presentation Type

Event

Full Name of Faculty Mentor

Bryan Wakefield

Major

Chemistry

Presentation Abstract

Phidianidine is a natural alkaloid that is unique to other alkaloids by containing a natural oxadiazole structure. This molecule was discovered in a marine species Phidiana militaris and has many pharmaceutical potentials including being an agonist towards the µ-opioid receptor and inhibiting the growth of cancer cell lines. These characteristics makes phidianidine a desirable molecule for synthesis. The lynchpin of previous methods was the construction of the central 1,2,4-oxadiazole ring which limited the types of analogues that could be constructed. The objective of this research is to develop a synthetic method that enables the late-stage installation of a variety of moieties to create new analogues of this alkaloid for biological evaluation.

Course

CHEM*499*06

Location

Lib Jackson Student Union, Atrium

Start Date

16-4-2019 12:30 PM

End Date

16-4-2019 2:30 PM

Disciplines

Chemistry

This document is currently not available here.

Share

COinS
 
Apr 16th, 12:30 PM Apr 16th, 2:30 PM

Alternative Methods in Synthesis of Phidianidine Analogues

Lib Jackson Student Union, Atrium

Phidianidine is a natural alkaloid that is unique to other alkaloids by containing a natural oxadiazole structure. This molecule was discovered in a marine species Phidiana militaris and has many pharmaceutical potentials including being an agonist towards the µ-opioid receptor and inhibiting the growth of cancer cell lines. These characteristics makes phidianidine a desirable molecule for synthesis. The lynchpin of previous methods was the construction of the central 1,2,4-oxadiazole ring which limited the types of analogues that could be constructed. The objective of this research is to develop a synthetic method that enables the late-stage installation of a variety of moieties to create new analogues of this alkaloid for biological evaluation.