Date of Award

Spring 2003

Document Type

Legacy Thesis

Degree Name

Bachelor of Science (BS)


Marine Science


College of Science

First Advisor

Brett Simpson


Marine sponges have been known to produce chemical compounds that exhibit bioactivity towards a variety of cancers and diseases. The fascaplysin alkaloids, first discovered in the 1980's, continue to command attention. These compounds represent potential leads for new therapeutics and/or molecular probes and can be obtained by synthesis or by isolation from marine invertebrates. Two novel compounds were isolated from an Indonesian collection of Fascaplysinopsis reticulata and were identified as brominated fascaplysins. The isolation process, elucidation of structures, and importance of such discoveries will be discussed.